ZeBiCa2: Zellfreie Biomineralisation

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Coordinator David Knies, M.Sc.

Partners KIT Karlsruhe, Alfred Wegener Institute Bremerhaven, University of Bielefeld

 

 

Description

Emiliania huxleyi is a species of calcifying algae that fixates calcium carbonate in form of coccoliths, regularly structured plates with a high specific surface. Goal of the ZeBiCa2 project is to understand E. huxleyi’s central metabolism and its connection to the calcification process.

To achieve this, we create a genome scale reconstruction from the annotated genome of E. huxleyi. The analysis of networks of this scale requires methods such as flux balance analysis, rely on a steady-state assumption for the metabolism. Since algae, as all photosynthetic organisms, follow a diurnal cycle of storage metabolite production and consumption, their metabolism can never be considered to be in a steady state. One objective at the Institute for System Dynamics is to expand these methods to account for diurnal cycles.

 

Publikations
  • D. Knies, P. Wittmüß, S. Appel, O. Sawodny, M. Ederer & R. Feuer, “Modeling and Simulation of Optimal Resource Management during the Diurnal Cycle in Emiliania huxleyi by Genome-Scale Reconstruction and an Extended Flux Balance Analysis Approach”, Metabolites, 5, pp. 659-676, 2015, doi:10.3390/metabo5040659

 

Funding        
The project is funded by the BMBF.
 
     

 

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