Medical Engineering

Contribution of system dynamics to medical technology

The ISYS medical engineering team is involved with modeling, simulation, control, state estimation and optimization of medical engineering applications. We cooperate with physicians of the Universitätsklinikum Tübingen and medical technology companies. Our work is part of the Inter-University Center for Medical Technology Stuttgart-Tübingen (IZST) [german].

Modern medical devices capture a multitude of electronic signals. Functions of medical devices can be actuated electronically. The methods of system dynamics can help to improve such devices in several ways and to make their operation safer and more ergonomic. Many medical measurement instruments provide physicians with data that is diagnostically difficult to interpret and contains artifacts. Mathematical models can be used to identify and remove artifacts as well as to process measured data and improve their diagnostic quality. Additionally, mathematical models can be used to design optimal feedforward or feedback control for surgical tools or to design instruments which could not be operated without complex controllers. Thereby, system dynamics contribute to the development of safe medical devices with a low risk of complication.

 

Research Projects
High-Definition Urethral Pressure Profilometry
  • Development of algorithms to reconstruct the spatial pressure distribution inside the urethra in high detail
  • Improved diagnosis of urinary incontinence
  • Improved verification of therapeutic success
Model-based optimization of bipolar radiofrequency-induced thermofusion
  • Thermofusion: an electrosurgical vessel sealing method
  • Modelling and analysis of the physical process
  • Optimization of the control algorithms to reduce the thermal damaging of the surrounding tissue
Interaction-based, Robot-supported Assistance Systems
  • Systematic analysis of the workplace ergonomics during laparocopic procedures
  • Design and development of a robot-based arm support system
Surgical Navigation for Laparoscopic Interventions
  • Surgical navigation system for vision-guided orientation during laparoscopic interventions
  • Fusion of absolute and inertial position data
  • Visualization of preoperatively identified structures
Model-based Intraoperative Identification of Soft Tissue Parameters
  • Tumor-localization and intraoperative discrimination of malign and benign tissue from mechanical properties
  • Sensor fusion using spectroscopic and mechanical data
  • Identification of viscoelastic parameters of soft tissue
Noninvasive Measurement of Glucose Concentrations via Metamaterials
  • Noninvasive method to determine the glucose concentration of tear fluid
  • Signal processing of the reflected beam
  • Determination of the glucose concentration via inverse model
 
Endoluminal Partial Bladder Wall Resection with Transurethral Extrication
  • Transurethral en-bloc extrication of bladder tumors
  • Model-based weak spot prediction in the bladder wall
  • Patient-friendly and lower recurrence rates
 

 

 

Student's Theses

We are always looking for students, who want to contribute to one of our research projects through a bachelor's or master's thesis. The assigned subjects typically include but are not limited to:

  • Distributed-parameter modeling of mechanical, electric and thermodynamic systems.
  • Solving inverse mathematical problems.
  • Sensor fusion and signal processing.
  • Methods of constrained and unconstrained optimization.
  • Methods of cooperative robotics and human-machine interaction.

If you are interested in one of our projects and would like to get more information, or if you'd like to inquire about additional topics, please don't hesitate to contact us.

 

Publications of the Medical Engineering Team
Journal Papers
  • M. Klünder, B. Amend, O. Sawodny, A. Stenzl, M. Ederer, A. Kelp, K.-D. Sievert & R. Feuer, “Assessing the reproducibility of high definition urethral pressure profilometry and its correlation with an air-charged system”, Neurourology and Urodynamics, pp. 1-9, 2016, doi:10.1002/nau.23115
  • M. Klünder, O. Sawodny, B. Amend, M. Ederer, A. Kelp, K.-D. Sievert, A. Stenzl & R. Feuer, “Signal processing in urodynamics: towards high definition urethral pressure profilometry”, BioMedical Engineering OnLine, 15, pp. 1-24, 2016, doi:10.1186/s12938-016-0145-6
  • J. Wagenpfeil, C. Schöllig, V. Mayer, R. Feuer, B. Nold, A. Neugebauer, M. Ederer, R. Rothmund, B. Krämer, S. Brucker, M. Enderle, O. Sawodny & J. Rex, “In silico evaluation of geometry variations with respect to the thermal spread during coagulation of egg white using bipolar vessel sealing instruments”, BioMedical Engineering OnLine, 2016, doi:10.1186/s12938-016-0238-2
  • M. Klünder, B. Amend, M. Vaegler, A. Kelp, R. Feuer, K.-D. Sievert, A. Stenzl, O. Sawodny & M. Ederer, “High Definition Urethral Pressure Profilometry: Evaluating a Novel Microtip Catheter”, Neurourology and Urodynamics, 2015, doi:10.1002/nau.22835
  • B. Steinhilber, S. Hoffmann, K. Karlovic, S. Pfeffer, T. Maier, O. Hallasheh, S. Kruck, R. Seibt, M. Rieger, M. Heidingsfeld, R. Feuer, O. Sawodny, R. Rothmund & K.-D. Sievert, “Development of an arm support system to improve ergonomics in laparoscopic surgery: study design and provisional results in Surgical Endoscopy”, Surgical Endoscopy, 29, pp. 2851-2858, 2015, doi:10.1007/s00464-014-3984-x
  • W. Aicher, M. Hart, J. Stallkamp, M. Klünder, M. Ederer, O. Sawodny, M. Vaegler, B. Amend, K. Sievert & A. Stenzl, “Towards a Treatment of Stress Urinary Incontinence:Application of Mesenchymal Stromal Cells for Regeneration of the Sphincter Muscle”, Journal of Clinical Medicine, pp. 197-215, 2014, doi:10.3390/jcm3010197
Conference Papers
  • M. Klünder, O. Sawodny & R. Feuer, “Increasing Spatial Resolution through Automated Catheter Rotation in High Definition Urethral Pressure Profilometry”, IEEE International Conference on Automation Science and Engineering (CASE), 2016
  • D. Claus, P. M. Schumacher, T. Labitzke, M. Mlikota, U. Weber, S. Schmauder, N. Schierbaum, T. E. Schäffer, P. Wittmuess, T. Teutsch, C. Tarín, S. Hoffmann, F. A. Taran, S. Brucker, J. Mischinger, A. Stenzel & W. Osten, “Intraoperative model based identification of tissue properties using a multimodal and multiscale elastographic measurement approach”, Proceedings of SPIE, 2015, pp. 95400M-1-95400M-6, doi:10.1117/12.2183876
  • D. Claus, P. M. Schumacher, M. Wilke, M. Mlikota, U. Weber, S. Schmauder, N. Schierbaum, T. E. Schäffer, P. Wittmuess, T. Teutsch, C. Tarín, S. Hoffmann, S. Brucker, J. Mischinger, C. Schwentner, A. Stenzl & W. Osten, “Intraoperative model based identification of tissue properties based on multimodal and multiscale measurements”, Proceedings of SPIE, 2015, pp. 932805-1-932805-5, doi:10.1117/12.2076831
  • M. Klünder, R. Feuer, B. Amend, A. Kelp, A. Stenzl, K.-D. Sievert, O. Sawodny & M. Ederer, “Eliminating Pulse-Induced Artifacts in Urethral Pressure Data”, International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milano, Italy, 2015, pp. 2779-2783, doi:10.1109/EMBC.2015.7318968
  • M. Klünder, R. Feuer, O. Sawodny & M. Ederer, “Using Deconvolution to Determine the Sphincter Strength Distribution Around the Urethra”, IEEE International Symposium on Medical Measurements and Applications (MeMeA), 2015, pp. 6-11, doi:10.1109/MeMeA.2015.7145163
  • F. Schlagenhauf, P.Wittmuess, C. Tarín, T. Teutsch & O. Sawodny, “Stiffness gradient detection for tissue discrimination based on identification of mass-spring-damper models”, IEEE Conference on Control Applications (CCA), Sydney, NSW, Australia, 2015, pp. 1057-1062, doi:10.1109/CCA.2015.7320752
  • T. Teutsch, M. Mesch, H. Giessen & C. Tarín, “Discrete wavelength selection for the optical readout of a metamaterial biosensing system for glucose concentration estimation via a support vector regression model”, International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milano, Italy, 2015, pp. 6421-6424, doi:10.1109/EMBC.2015.7319862
  • J. Wagenpfeil, M. Jung, B. Nold, A. Neugebauer, M. Ederer, B. Krämer, R. Rothmund, C. Schwentner, D. Wallwiener, A. Stenzl, M. Schenk, M. Enderle, O. Sawodny & R. Feuer, “Optimized generator modes for bipolar vessel sealing”, IEEE Conference on Control Applications (CCA), Sydney, NSW, Australia, 2015, pp. 1862-1867, doi:10.1109/CCA.2015.7320881
  • J. Wagenpfeil, C. Schöllig, V. Mayer, B. Nold, M. Ederer, A. Neugebauer, R. Rothmund, B. Krämer, C. Schwentner, M. Schenk, M. Enderle, O. Sawodny & R. Feuer, “Finite-Element-Modeling of Egg White as a Substitute for Tissue Coagulation during Bipolar Radiofrequency-Induced Thermofusion”, International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015, doi:10.1109/EMBC.2015.7319708
  • M. Heidingsfeld, R. Feuer, K. Karlovic, T. Maier & O. Sawodny, “A Force-controlled Human-assistive Robot for Laparoscopic Surgery”, IEEE International Conference on Systems, Man and Cybernetics, 2014, pp. 3435-3439, doi:10.1109/SMC.2014.6974460
  • M. Klünder, O. Sawodny, R. Feuer, A. Stenzl, K.-D. Sievert, B. Amend, M. Vaegler & M. Ederer, “Sampling lattice and signal reconstruction in urodynamics”, Signal Processing (ICSP) 12th International Conference on, 2014, pp. 1790-1796, doi:10.1109/ICOSP.2014.7015302
  • P. Rapp, L. Hägele, O. Sawodny & C. Tarín, “Characterization of a 6 DOF Acoustic-Inertial Navigation System for Minimally-Invasive Surgery”, International Conference on Control, Automation, Robotics & Vision (ICARCV), 2014, pp. 1823-1828, doi:10.1109/ICARCV.2014.7064593
  • P. Rapp, L. Hägele, O. Sawodny & C. Tarín, “Performance Study for an Acoustic-Inertial Close Range Navigation System used in Minimally-Invasive Surgical Interventions”, European Control Conference (ECC), Strasbourg, France, 2014, pp. 344-351, doi:10.1109/ECC.2014.6862302
  • P. Rapp, O. Sawodny, C. Tarín, C. R. Pech, J. Mischinger & C. Schwentner, “A Concept for a Novel Surgical Navigation System”, IEEE International Conference on Systems, Man, and Cybernetics, 2014, pp. 3884-3889, doi:10.1109/SMC.2014.6974537
  • T. Teutsch, M. Mesch, H. Giessen & C. Tarín, “Dynamic modeling of the hydrogel molecular filter in a metamaterial biosensing system for glucose concentration estimation”, International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Chicago, IL, USA, 2014, pp. 2081-2084, doi:10.1109/EMBC.2014.6944026
  • J. Wagenpfeil, B. Nold, K. Fischer, A. Neugebauer, R. Rothmund, B. Krämer, S. Brucker, J. Mischinger, C. Schwentner, M. Schenk, D. Wallwiener, A. Stenzl, M. Enderle, O. Sawodny & M. Ederer, “A Mathematical Model of Bipolar Radiofrequency-Induced Thermofusion”, International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Chicago, IL, USA, 2014, pp. 5683-5686, doi:10.1109/EMBC.2014.6944917
Other Publications

 

Members of the Medical Engineering Team
Prof. Dr.-Ing. Cristina Tarín mailto icon cristina.tarin
Dipl.-Biol. (t.o.) Julia Rex mailto icon julia.rex
Dipl.-Ing. Michael Heidingsfeld mailto icon michael.heidingsfeld
Dipl.-Ing. Philipp Rapp mailto icon philipp.rapp
Dipl.-Ing. Tanja Teutsch mailto icon tanja.teutsch
Dipl.-Ing. Jay Wagenpfeil mailto icon jay.wagenpfeil